10 research outputs found
Optical imaging of strain in two-dimensional crystals
Strain engineering is widely used in material science to tune the
(opto-)electronic properties of materials and enhance the performance of
devices. Two-dimensional atomic crystals are a versatile playground to study
the influence of strain, as they can sustain very large deformations without
breaking. Various optical techniques have been employed to probe strain in
two-dimensional materials, including micro-Raman and photoluminescence
spectroscopy. Here we demonstrate that optical second harmonic generation
constitutes an even more powerful technique, as it allows to extract the full
strain tensor with a spatial resolution below the optical diffraction limit.
Our method is based on the strain-induced modification of the nonlinear
susceptibility tensor due to a photoelastic effect. Using a two-point bending
technique, we determine the photoelastic tensor elements of molybdenum
disulfide. Once identified, these parameters allow us to spatially image the
two-dimensional strain field in an inhomogeneously strained sample.Comment: 13 pages, 4 figure
Second harmonic generation in strained transition metal dichalcogenide monolayers: MoS2, MoSe2, WS2, and WSe2
Second-harmonic generation (SHG) is a powerful measurement technique to analyze the symmetry properties of crystals. Mechanical strain can reduce the symmetry of a crystal and even weak strain can have a considerable impact on the SHG intensity along different polarization directions. The impact of strain on the SHG can be modeled with a second-order nonlinear photoelastic tensor. In this work, we determined the photoelastic tensors at a fundamental wavelength of 800 nm for four different transition metal dichalcogenide (TMD) monolayers: MoS2, MoSe2, WS2, and WSe2. Strain is applied using a three-point bending scheme, and the polarization-resolved SHG pattern is measured in backscattering geometry. Furthermore, we connected the strain dependent SHG with the strain dependence of the A-exciton energy. With the second-order nonlinear photoelastic tensor, full strain information can be accurately extracted from polarization-resolved SHG measurements. Accordingly, uniaxial strain, induced by polydimethylsiloxan (PDMS) exfoliation and transfer, is measured. We find that TMD monolayers fabricated with PDMS are strained by ∼0.2%. With the experimentally determined nonlinear photoelastic tensors, it will be possible to optically probe arbitrary strain fields in TMD monolayers
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway
The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates cardiac gene expression. Here we show that the levels of an N-terminal proteolytically derived fragment of HDAC4, termed HDAC4-NT, are lower in failing mouse hearts than in healthy control hearts. Virus-mediated transfer of the portion of the Hdac4 gene encoding HDAC4-NT into the mouse myocardium protected the heart from remodeling and failure; this was associated with decreased expression of Nr4a1, which encodes a nuclear orphan receptor, and decreased NR4A1-dependent activation of the hexosamine biosynthetic pathway (HBP). Conversely, exercise enhanced HDAC4-NT levels, and mice with a cardiomyocyte-specific deletion of Hdac4 show reduced exercise capacity, which was characterized by cardiac fatigue and increased expression of Nr4a1. Mechanistically, we found that NR4A1 negatively regulated contractile function in a manner that depended on the HBP and the calcium sensor STIM1. Our work describes a new regulatory axis in which epigenetic regulation of a metabolic pathway affects calcium handling. Activation of this axis during intermittent physiological stress promotes cardiac function, whereas its impairment in sustained pathological cardiac stress leads to heart failure